An Ugi Reaction/Intramolecular Cyclization/Oxidation Cascade towards Tetrazole-Linked Dibenzoxazepines
نویسندگان
چکیده
Abstract A series of tetrazole-linked dibenzo[b,f][1,4]oxazepines is synthesized through a short sequence involving an Ugi tetrazole reaction. The intermediate undergoes potassium carbonate mediated SNAr cyclization, followed by oxidation to afford the target tricyclic heterocyclic scaffold. optimization, scope and limitations this two-step efficient methodology are investigated. 1000-member library generated physicochemical properties analyzed. great
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ژورنال
عنوان ژورنال: Synthesis
سال: 2021
ISSN: ['1791-5155', '1791-5856']
DOI: https://doi.org/10.1055/s-0040-1706642